O-isopropyl ethylthiocarbamate

Toxicity to terrestrial plants

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to terrestrial plants: long-term

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.

Qualifier:

according to guideline

Guideline:

other: QSAR

Principles of method if other than guideline:

EPI Suite v 4.1/ECOSARv1.00

GLP compliance:

no

Remarks:

not applicable. QSAR model

Analytical monitoring:

not required

Vehicle:

no

Species:

other: Terrestrial plants,QSAR model

Plant group:

other: QSAR model

Details on test organisms:

no further information

Test type:

other: QSAR

Study type:

other: QSAR

Substrate type:

other: QSAR

Limit test:

no

Total exposure duration:

30 d

Test temperature:

not applicable. QSAR model

pH:

not applicable. QSAR model

Moisture:

not applicable. QSAR model

Details on test conditions:

SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate)

Reference substance (positive control):

no

Species:

other: Terrestrial plants,QSAR model

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

4.529 mg/kg soil dw

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

not specified

Remarks on result:

other: 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Species:

other: Terrestrial plants,QSAR model

Duration:

30 d

Dose descriptor:

NOEC

Effect conc.:

2.156 mg/kg soil dw

Nominal / measured:

not specified

Conc. based on:

not specified

Basis for effect:

not specified

Remarks on result:

other: cited as a ChV value, 1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Details on results:

The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 2.156 mg/L (ppm) for terrestrial plants.
The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 4.529 mg/L (ppm) for terrestrial plants.
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Overview of QSARs estimations ontoxicity of O-isopropyl ethylthiocarbamate (IPETC ) to terrestrial plants 

Method	Results	Remarks	Reference
QSAR estimate	Terrestrial plants ,96-hrEC50 = 4.529 mg/L (ppm)  Terrestrial plants, 30-day, ChV (chronic value) =2.156 mg/L(ppm)	Reliable with restrictions, QSAR estimated data	ECOSAR Program (v1.00)

 

 

 Terrestrial plants ,96-hrEC50 = 4.529 mg/L (ppm)

 Terrestrial plants, 30-day, ChV (chronic value) =2.156 mg/L(ppm)

1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for chemicals properties assessment.

Conclusions:

The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 2.156 mg/L (ppm) for terrestrial plants.
The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 4.529 mg/L (ppm) for terrestrial plants.
1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Executive summary:

The ECOSAR QSAR model predicts that 30-day, NOEC cited as a ChV value would to be 2.156 mg/L (ppm) for terrestrial plants.

The ECOSAR QSAR model predicts that 96-hr EC50 valuewould to be 4.529 mg/L (ppm) for terrestrial plants.

1 kg of water has a volume of 1 L and the mg/kg and mg/L are the same.

Reference 2

Endpoint:

toxicity to terrestrial plants: short-term

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Justification for type of information:

Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamate . Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate .

Qualifier:

no guideline followed

Principles of method if other than guideline:

The inhibition of germination produced by the test compound applied in solution to a seed was determined. Inhibitory activity was expressed as the millimolar concentration of the compound producing 50 per cent inhibition at the given temperature.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Details on preparation and application of test substrate:

The compound was applied in solution to a seed.

Species:

Lactuca sativa

Plant group:

Dicotyledonae (dicots)

Details on test organisms:

Details on test organisms
- Common name: garden lettuce
- Plant family: Asteraceae
- Variety: Great Lakes
- Source of seed: Sutton and Son Ltd.
- Prior seed treatment/sterilization: Not reported
- Historical germination of seed (germination of seed lot tested): Not reported
- Seed storage: Not reported

Test type:

seed germination/root elongation toxicity test

Study type:

laboratory study

Substrate type:

not specified

Limit test:

no

Total exposure duration:

3 d

Test temperature:

30ºC

pH:

not reported

Moisture:

not reported

Details on test conditions:

not reported

Nominal and measured concentrations:

not reported

Species:

Lactuca sativa

Duration:

3 d

Dose descriptor:

EC50

Effect conc.:

2 100 other: mg/l

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

germination

Remarks on result:

other: 95% CL 35 ± 12 mM

Details on results:

EC50 ( 3 d) = 2100 mg/l (inhibition of seed germination)

Validity criteria fulfilled:

not applicable

Conclusions:

A 3 d EC50 of 2100 mg/l has been determined for inhibition of seed germination to Lactuca sativa of the test substance.Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate. Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate .

Executive summary:

A3 d EC50 of 2100mg/l has been determined for inhibition of seed germination to Lactuca sativaof the test substance.  

Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamateand .Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate.

Description of key information

A3 d EC50of2100mg/l has been determined for inhibition of seed germinationto Lactuca sativaof the test substance. 
Propan-2 -ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/O-isopropyl ethylthiocarbamate.Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/O-isopropyl ethylthiocarbamate 

Key value for chemical safety assessment

Short-term EC50 or LC50 for terrestrial plants:

2 100 mg/kg soil dw

Long-term EC10, LC10 or NOEC for terrestrial plants:

420 mg/kg soil dw

Additional information

A3 d EC50 of 2100mg/l has been determined for inhibition of seed germination to Lactuca sativa of the test substance. 

Propan-2-ol (Isopropyl alcohol) is both reagents used in the manufacture of IPETC/ O-isopropyl ethylthiocarbamatea.Therefore, Propan-2-ol (Isopropyl alcohol) need to be considered in the assessment of IPETC/ O-isopropyl ethylthiocarbamate.