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EC number: 205-517-7 | CAS number: 141-98-0
Toxicity to aquatic plants other than algae
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic plants other than algae
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for organic chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- ECOSAR Program(v1.00)
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: QSAR model
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 d
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 4.529 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.156 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Details on results:
- A 96 h LC50 value of 4.529 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
The data show the multi-component substances containing O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol
to be acutely toxic at concentrations of between 2.156-4.529 mg/L.
This result signifies that the test substance is expected to be moderately toxic.
A NOEC value of 2.156 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
This result signifies that the test substance is expected to be moderately toxic.
. - Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for organic chemicals properties assessment.
- Conclusions:
- A 96 h LC50 value of 4.529 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
The data show the multi-component substances containing O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol
to be acutely toxic at concentrations of between 2.156-4.529 mg/L.
This result signifies that the test substance is expected to be moderately toxic.
A NOEC value of 2.156 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
This result signifies that the test substance is expected to be moderately toxic.
. - Executive summary:
A 96 h LC50 value of 4.529 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
The data show the multi-component substances containing O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol
to be acutely toxic at concentrations of between 2.156-4.529 mg/L.
This result signifies that the test substance is expected to be moderately toxic.
A NOEC value of 2.156 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
This result signifies that the test substance is expected to be moderately toxic.
.
Reference
Overview of QSARs estimations onaquatic toxicity of O-isopropyl ethylthiocarbamate (IPETC ) to algae and aquatic plants
Method
|
Results |
Remarks |
Reference |
QSAR estimate |
Green Algae, 96-hr EC50 =4.529mg/L (ppm) Green Algae, 30-day, NOEC cited as a ChV value = 2.156mg/L(ppm)
|
Reliable with restrictions, QSAR estimated data |
ECOSAR Program (v1.00) |
Green Algae, 96-hr EC50 =4.529mg/L (ppm)
Green Algae, 30-day, NOEC cited as a ChV value = 2.156 mg/L(ppm)
Description of key information
A 96 h LC50 value of 4.529 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
The data show the multi-component substances containing O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol
to be acutely toxic at concentrations of between 2.156-4.529 mg/L.
This result signifies that the test substance is expected to be moderately toxic.
A NOEC value of 2.156 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
This result signifies that the test substance is expected to be moderately toxic.
Key value for chemical safety assessment
- EC50 for freshwater plants:
- 4.529 mg/L
- EC50 for marine water plants:
- 0.453 mg/L
- EC10 or NOEC for freshwater plants:
- 2.156 mg/L
- EC10 or NOEC for marine water plants:
- 0.216 mg/L
Additional information
A 96 h LC50 value of 4.529 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
The data show the multi-component substances containing O-isopropyl ethylthiocarbamate and n-butanol and propan-2-ol
to be acutely toxic at concentrations of between 2.156-4.529 mg/L.
This result signifies that the test substance is expected to be moderately toxic.
A NOEC value of 2.156 mg/L has been calculated for the effects of the test substance on the mortality of the Algae group.
This result signifies that the test substance is expected to be moderately toxic.
The available data for saltwater aquatic plants other than algae are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa
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