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Ecotoxicological information

Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
SPECIES
SPECIES #
(NAME): 4 Oncorhynchus mykiss (Rainbow Trout)
AGE: NR NR
LIFE STAGE: fingerling
COMMENT: 1-10 G
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
348 mg/L CaCO3
ALKALINITY: 203 mg/L CaCO3
Test temperature:
12 0C
pH:
8.6
Dissolved oxygen:
Saturated mg/l
Salinity:
SALINITY:NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F NR 45000 TO 48 000 45000 TO 48000 ug/L NR
F NR 40000 TO 45 000 40000 TO 45000 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F NR 45000 TO 48 000 45000 TO 48000 ug/L NR
F NR 40000 TO 45 000 40000 TO 45000 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 12 NR TO NR C
pH: 8.6 NR TO NR
HARDNESS: 348 NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: 203 NR TO NR mg/L CaCO3
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 40 - < 45 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 45 - < 48 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 9 mg/l (NOEC). One of the 96h-LC50 was between 45 and 48 mg/l
Details on results:
EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE:NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality

ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)
GENERAL COMMENTS: LOC/NR// HARD,ALK,PH/OF DILUTION H2O// AERATED//
Validity criteria fulfilled:
yes
Conclusions:
Under the conditions of the present test O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to guideline
Guideline:
other: QSAR
Principles of method if other than guideline:
EPI Suite v 4.1/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fishes species
Details on test organisms:
no further information
Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Details on test conditions:
SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate)







Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
7.856 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Details on results:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 7.856 mg/l was established.
Fish, 96-hr LC50 =7.856 mg/L (ppm)
Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 7.856 mg/l was established.
Fish, 96-hr LC50 = 7.856 mg/L (ppm)
Fish, 96-hr (SW) LC50 = 9.881mg/L (ppm)
Fish 30-day ChV = 0.894 mg/L (ppm)
Fish (SW) 30-day ChV = 2.441mg/L (ppm
Fish, 14-dayLC50 = 8.114mg/L (ppm)

Executive summary:

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 7.856 mg/l therefore the substance is moderately toxic to fishes.

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to guideline
Guideline:
other: QSAR
Principles of method if other than guideline:
EPI Suite v 4.1/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fishes species
Details on test organisms:
no further information
Test type:
other: QSAR model
Water media type:
saltwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Details on test conditions:
SMILES : O(C(=NCC)S)C(C)C
CHEM : Carbamothioic acid, ethyl-, O-(1-methylethyl) ester
CAS Number: 141-98-0
MOL FOR: C6 H13 N1 O1 S1
MOL WT : 147.24
Log Kow: 3.32 (KowWin estimate)
Wat Sol: 114.4 mg/L (WskowWin estimate)







Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
9.881 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Details on results:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for marine water fish of 9.881 mg/l was established.
Fish, 96-hr LC50 =9.881 mg/L (ppm)
Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for marine water fish of 9.881 mg/l was established.
Fish, 96-hr LC50 = 7.856 mg/L (ppm)
Fish, 96-hr (SW) LC50 = 9.881mg/L (ppm)
Fish 30-day ChV = 0.894 mg/L (ppm)
Fish (SW) 30-day ChV = 2.441mg/L (ppm
Fish, 14-dayLC50 = 8.114mg/L (ppm)

Executive summary:

The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be 9.881 mg/l therefore the substance is moderately toxic to fishes.

Description of key information

Under the conditions of  of the study of  Fuerstenau,M.C., B.M. Wakawa, R.K. Price, and R.D. Wellik,1974 O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss  (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l  and therefore the substance is slightly toxic to fishes. 
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 7.856 mg/l therefore the substance is moderately toxic to fishes. 
The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be 9.881 mg/l therefore the substance is moderately toxic to fishes.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
7.856 mg/L

Marine water fish

Marine water fish
Effect concentration:
9.881 mg/L

Additional information

Under the conditions of of the study of Fuerstenau,M.C., B.M. Wakawa, R.K. Price, and R.D. Wellik,1974 O-isopropyl ethylthiocarbamate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 8 mg/l (NOEC). One of the 96h-LC50 was between 40 and 45 mg/l and therefore the substance is slightly toxic to fishes.

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fishwould to be7.856 mg/l therefore the substance is moderately toxic to fishes.

The ECOSAR QSAR model predicts that the 96hr LC50for marine water fishwould to be 9.881 mg/l therefore the substance is moderately toxic to fishes.