Registration Dossier
Registration Dossier
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EC number: 229-761-9 | CAS number: 6711-48-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F. and Carpenter C.P.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Ass. J., 23,|95-107
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Penetration of rabbit skin is estimated by a technique closely akin to the one-day, cuff Method of Draize.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- EC Number:
- 229-761-9
- EC Name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- Cas Number:
- 6711-48-4
- Molecular formula:
- C10H25N3
- IUPAC Name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- Details on test material:
- Name of test material (as cited in study report): N,N,N`,N`-Tetramethyldipropylenetriamine
1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3-5 months
- Mean weight at study initiation: 2.5 -3.5 kg
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: No data.
- % coverage: No data.
- Type of wrap if used: Impervious plastic film (Cuff method of Draize).
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not more than 20 ml/kg bw. - Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4 males/treatment
- Control animals:
- not specified
- Details on study design:
- Animals were observed for signs of toxicity after dosing, and throughout the 14-day observation interval. Animals that died on study were subjected to necropsy; animals sacrificed at the end of the observation interval were also necropsied.
- Statistics:
- Thompson's method of calculating the LD50 was applied to the 14-day mortality data.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 260 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Corresponding to 0,31 mL/kg, calculated with a density of 0,8395 g/mL.
- Mortality:
- No data.
- Clinical signs:
- No data.
- Body weight:
- No data.
- Gross pathology:
- No data.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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