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EC number: 229-761-9 | CAS number: 6711-48-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 05, 1997 - May 08, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- EC Number:
- 229-761-9
- EC Name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- Cas Number:
- 6711-48-4
- Molecular formula:
- C10H25N3
- IUPAC Name:
- N'-[3-(dimethylamino)propyl]-N,N-dimethylpropane-1,3-diamine
- Details on test material:
- - Name of test material (as cited in study report): Bis- (3-dimethylaminopropyl)amin
- Analytical purity: 98.4 %
- Lot/batch No.: 94-0675
- Physical state: Liquid
- Stability: The stability of the test substance over the study period was proven by reanalysis
- Homogeneity: The test substance is homogeneous
- Solubility in water: Miscible up to 10 g/L
- Stability in water: The test substance was stable in the carrier for the period specified
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test solutions were prepared separately for each test concentration. The substance was added to the test medium and stirred with an ultraturrax.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: Charles River Aquatics, Someren; Netherlands
- Age at study initiation (mean and range, SD): 8 month and 3 month respectively
- Length at study initiation (length definition, mean, range and SD): 1) 3.30 cm (range 2.8 - 4.0 cm); 2) 2.85 cm (2.6 - 3.2 cm)
- Weight at study initiation (mean and range, SD): 1) 0.29 g (0.18 - 0.48 g); 2) 0.24 g (0.20 - 0.40 g)
ACCLIMATION
- Acclimation period: 14 d
- Type and amount of food: TETRA MIN standard feed for aquarium fish TETRA - WERKE, Melle, Germany, ad libitum; and on workdays generally additionally live artemia
- Feeding frequency: daily
- Health during acclimation (any mortality observed): 1) no mortality observed 2) 4.3 %
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.55 mmol/l
- Test temperature:
- 21 - 24 °C
- pH:
- 8.3 - 10.2 (neutralised sample: 8.2)
- Dissolved oxygen:
- 7.6 - 8.7 mg/L
- Nominal and measured concentrations:
- Nominal test concentrations (mg/L): 0 (control), 0 (control), 1.0, 2.15, 4.64, 10.0, 21.5, 46.4, 100, 215, 464, 1000, 1000 (neutralised)
Analytically determined concentrations (mg/L): < 1 mg/L (control), 1.3, 2.2, 4.7, 9.9, 21.2, 47, 100, 220, 470, 1000, 1030 - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria (30 x 22 x 24 cm)
- Fill volume: 10 L
- Aeration: slight
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 0.29 g fish/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Municipal water of the City of Frankenthal, not chlorinated and passed through a charcoal filter, aerated
- Total hardness: ca. 2.5 mmol/L
- Acid capacity: ca. 5.5 mmol/L
- Ca content: ca. 90 mg/L
- Mg content: ca. 10 mg/L
- pH: ca. 8.0 - 8.6
OTHER TEST CONDITIONS
- Photoperiod: 16:8 h day-night regime
- Feeding: Withdrawal of food: 1 day before and during exposure
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mortality and symptoms of intoxication after 1, 4, 24, 48, 72 and 96 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2.2
- Results used to determine the conditions for the definitive study: LC 50 (96 h): >100 and <1000 mg/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 21.4 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 21.4 - 47 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 21.4 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 215 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 68 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: The LC50 was determined by calculating the geometric mean between the highest concentration causing no mortality and the lowest concentration producing 100% mortality.
- Details on results:
- Observed symptoms: apathy, tumbling, swimming near water surface
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Measured pH-values:
Test item concentration (mg/l; nominal)
pH after (h)
1 h
24 h
48 h
72 h
96 h
0
8.3
8.3
8.3
8.3
8.3
0
8.4
8.5
8.6
8.6
8.6
1
8.3
8.2
8.2
8.3
8.3
2.15
8.4
8.3
8.2
8.3
8.3
4.64
8.4
8.4
8.3
8.3
8.3
10.0
8.5
8.4
8.4
8.4
8.5
21.5
8.7
8.4
8.4
8.5
8.5
46.4
8.8
8.6
8.6
8.6
8.7
100
9.1
8.7
8.7
8.6
8.7
215
9.3
9.1
464
9.7
1000
10.2
1000*
8.2
* pH-adjusted
Mortality:
Test item concentration (mg/l; nominal)
Dead fish after (h)
1 h
4 h
24 h
48 h
72 h
96 h
0
0
0
0
0
0
0
0
0
0
0
0
0
0
1
0
0
0
0
0
0
2.15
0
0
0
0
0
0
4.64
0
0
0
0
0
0
10.0
0
0
0
0
0
0
21.5
0
0
0
0
0
0
46.4
0
0
1
5
7
8
100
0
0
0
6
7
7
215
0
0
10
10
10
10
464
0
10
10
10
10
10
1000
10
10
10
10
10
10
1000*
0
10
10
10
10
10
* pH-adjusted
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.