N-methoxy-1-(2,4,6-trichlorophenyl)propan-2-amine

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22 October 2013 to 28 January 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Decomp. temp.:

ca. 184 °C

Remarks on result:

not determinable

Remarks:

due to thermal decomposition, the boiling point cannot be determined.

From comparison of the thermographic profiles obtained from samples analyzed using pre-perforated  crucible lids (which allow self-pressurisation up to the boiling temperature) and those using manually pierced crucible lids (i.e. an open system), it can be confirmed that the observed endothermal event did not originate from the boiling of the test item.  This was since an open system allows premature evaporation of volatile substances during heating, resulting in a broader endotherm, with lower, more variable extrapolated onset temperatures.  The pre-perforated crucible lids however retained any initial vapour within the crucible, until the exponential increase in pressure as the boiling temperature is reached. This results in much narrower, focused endotherms.  However, as an identical thermographic profile was observed for all sample replicates, under both sets of experimental conditions, and combined with a remaining dark brown residue, the endotherm has been attributed to decomposition of the test item, not boiling.  Such a process may remain endothermic, as energy is required to break chemical bonds within the structure.

The use of manually pierced crucibles (an open system) also provided an opportunity to assess the stability of the test item in air and in an inert atmosphere (nitrogen). As decomposition was evident under both air and nitrogen atmospheres, this was most likely a thermal process, as opposed to oxidative.

From the six determinations, a mean onset temperature of 187 °C (460 K) was obtained from the pre-endotherm baseline limit values, with a relative standard deviation value of 1.4%.  The mean extrapolated onset temperature was 208 °C (480 K) with a relative standard deviation value of 0.52%.  However, the overall conclusion has been taken as the lowest onset temperature at which decomposition was detected, in order to present a worst case scenario for thermal stability.

Conclusions:

The test item decomposed on heating from approximately 184 °C (457 K), both in air and under a nitrogen atmosphere, at 102.3 to 103.1 kPa

Therefore, due to thermal decomposition, the boiling point cannot be determined.

Executive summary:

The study was performed to determine the boiling temperature of the test item.  

The method employed was designed to be compatible with OECD Guidelines for Testing of Chemicals, Section 1, No. 103: “Boiling Point/Boiling Range” adopted 27 July 1995, and Method A2 Boiling Temperature of Commission Regulation (EC) No 440/2008, dated May 30, 2008.

The test item decomposed on heating from approximately 184 °C (457 K), both in air and under a nitrogen atmosphere, at 102.3 to 103.1 kPa

Therefore, due to thermal decomposition, the boiling point cannot be determined.

Description of key information

The test item decomposed on heating from approximately 184 °C (457 K), both in air and under a nitrogen atmosphere, at 102.3 to 103.1 kPa

Therefore, due to thermal decomposition, the boiling point cannot be determined.