Registration Dossier
Registration Dossier
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EC number: 276-337-4 | CAS number: 72102-30-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo, other
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- Three invitro gene mutation studies were conducted:
- the Mammalian Cell Gene Mutation test using the HPRT genes following OECD 476
Three invitro/exvivo gene mutation studies were conducted:
- the Mammalian Cell Gene Mutation test using the HPRT genes following OECD 476
- the Bacterial Reverse Mutation Test / Ames test following OECD 471 and EU B.13/14
- the Mammalian Cell Micronucleus Test following OECD 487 and EU B.49
As two of the three conducted invitro/exvivo tests exhibited clear negative results, and one test, the Mammalian Cell Micronucleus Test, exhibited not a positive, but an ambiginous test, no further invivo testing on gentoxicity is scientifically necessary and responsible with respect to the animal protection provisions.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
