N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-11-10 to 2018-02-13

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

no

Type of method:

effusion method: vapour pressure balance

Temp.:

20 °C

Vapour pressure:

< 0 Pa

Temp.:

25 °C

Vapour pressure:

< 0 Pa

Temp.:

50 °C

Vapour pressure:

< 0 Pa

The vapour pressure was measured in the temperature range of 30 °C to 110 °C. The measured vapour pressures at the corresponding temperatures are listed in Table 1 below. The mass of test item was determined (with Sartorius R200D) before (0.4887 g) and after (0.4850 g) the vapour pressure measurement. A mass loss of approx. 1% (w/w) was observed.

Table 1: Measured vapour pressures and corresponding temperatures

Temperature / °C	Vapour pressure / hPa
30	not evaluable
40	2.2 x 10E-6
50	not evaluable
60	3.5 x 10E-6
70	2.5 x 10E-6
80	2.3 x 10E-6
90	2.5 x 10E-6
100	3.3 x 10E-6
110	not evaluable

The test did not yield vapour pressures sufficiently high (values are below the detection limit) for an evaluation. Hence, no regression could be made to extrapolate to 20, 25, and 50 °C, and these values were estimated using the Antoine equation. The detection limite (1 x 10E-5 hPa) at the highest measurement point (110 °C) was used for the calculation as all measured vapour pressures were below the detection limit.

Conclusions:

The vapour pressure of the test item was determined according to OECD guideline 104 by effusion method using a vapour pressure balance. The vapour pressure was measured in the temperature range of 30 °C to 110 °C. However, the measured values were below the detection limit and therefore the vapour pressures for 20 °C, 25 °C and 50 °C were estimated using the Antoine equation:
20 °C: < 9.9 x 10E-8 Pa;
25 °C: < 1.9 x 10E-7 Pa;
50 °C: < 3.8 x 10E-6 Pa.

Executive summary:

The vapour pressure of the test item was determined according to OECD guideline 104 by effusion method using a vapour pressure balance. The vapour pressure was measured in the temperature range of 30 °C to 110 °C. However, the measured values were below the detection limit and therefore the vapour pressures for 20 °C, 25 °C and 50 °C were estimated using the Antoine equation:

20 °C: < 9.9 x 10E-8 Pa;

25 °C: < 1.9 x 10E-7 Pa;

50 °C: < 3.8 x 10E-6 Pa.

This is a conservative estimation of the vapour pressure of the test item for the listed temperatures.

Description of key information

The vapour pressure of the test item was determined according to OECD guideline 104 by effusion method using a vapour pressure balance. The vapour pressure was measured in the temperature range of 30 °C to 110 °C. However, the measured values were below the detection limit and therefore the vapour pressures for 20 °C, 25 °C and 50 °C were estimated using the Antoine equation:

20 °C: < 9.9 x 10E-8 Pa;

25 °C: < 1.9 x 10E-7 Pa;

50 °C: < 3.8 x 10E-6 Pa.

This is a conservative estimation of the vapour pressure of the test item for the listed temperatures.