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Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute toxicity
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus DATABASE, 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity study of test chemical in Rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-phenylbutenone
EC Number:
204-555-1
EC Name:
4-phenylbutenone
Cas Number:
122-57-6
Molecular formula:
C10H10O
IUPAC Name:
(3E)-4-phenylbut-3-en-2-one
Details on test material:
- IUPAC Name: 4-phenylbutenone- Smiles: c1(\C=C\C(C)=O)ccccc1- InChI: 1S/C10H10O/c1-9(11)7-8-10-5-3-2-4-6-10/h2-8H,1H3/b8-7+- Molecular formula :C10H10O- Molecular weight :146.188 g/mole- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
2031 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for mortality and clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 031 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 2031 mg/kg bw
Clinical signs:
Clinical signs were observed as follows, regional or general arteriolar or venous dilation; behavioral changes; muscle weakness; changes in skin and appendages (skin), hairs and other.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The LD50 was considered to be 2031 mg/kg bw, when rats were treated with test chemical via oral route.
Executive summary:

The acute oral toxicity of test chemical was tested in rats at the dose concentration of 2031 mg/kg bw. Animals were observed for mortality and clinical signs. 50% mortality was observed at 2031 mg/kg bw. Clinical signs were observed as follows, regional or general arteriolar or venous dilation; behavioral changes; muscle weakness; changes in skin and appendages (skin), hairs and other. Hence, LD50 value was considered to be 2031 mg/kg bw, when rats were treated with test chemical via oral route.