Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as- 1. and 2.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material : Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates- Substance type: Organic- Physical state: Solid

Radiolabelling:

not specified

Analytical monitoring:

not specified

Temp.:

55 °C

Remarks:

(1) During the study pH ranges from 5-9, respectively.

Remarks:

(2) Not specified

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

Temp.:

55 °C

DT50:

> 29 - < 146 d

Remarks on result:

other: pH ranges from 5-9, respectively

pH:

7

Temp.:

25 °C

Hydrolysis rate constant:

0 s-1

DT50:

38 d

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates can be expected to be range from > 29 to < 146 days, respectively. Thus, based on this, test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates is considered to be not hydrolysable in water.

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates.The studies are as mentioned below:

The half-life value of test chemical was determinedat a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test substance is not hydrolysable.

In an another study, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec.The half-life of test substance was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates can be expected to be range from  > 29 to  < 146 days, respectively. Thus, based on this, test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates is considered to be not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates can be expected to be range from  > 29 to  < 146 days, respectively. Thus, based on this, test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates is considered to be not hydrolysable in water.

Key value for chemical safety assessment

Half-life for hydrolysis:

29 d

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates.The studies are as mentioned below:

The half-life value of test chemical was determinedat a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test substance is not hydrolysable.

In an another study, the half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec.The half-life of test substance was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates can be expected to be range from  > 29 to  < 146 days, respectively. Thus, based on this, test chemical Reaction mass of Benzenamine, N,N-dimethyl- , molybdate, tungstate & phosphates is considered to be not hydrolysable in water.