Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 259-583-7 | CAS number: 55302-96-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Dermal absorption:
One key study is available for dermal absorption. In this study, the dermal absorption (sum of the amounts measured in the living epidermis, dermis and receptor fluid) of Imexine OAG incorporated at 1.5% (final concentration) in a typical oxidative hair dye formulation was estimated to be 2.58 ± 1.03 μg/cm² (1.49-4.56 μg/cm²) in use conditions. The maximal penetration in non-oxidative conditions was 3.44 ± 1.89 μg/cm² (1.10-5.55 μg/cm²). The maximum absorption in a typical oxidative hair dye formulation was 4.56 μg/cm² (epidermis + dermis + receptor fluid) which corresponds to 1.56% of the applied dose. This figure is used for the calculation of the Margin of Safety. For REACh worker safety, the maximal absorption in non-oxicdative conditions was 5.55 μg/cm² (epidermis + dermis + receptor fluid) which corresponds to 2.05% of the applied dose.
Toxicokinetics:
No study available for this endpoint.
Key value for chemical safety assessment
- Absorption rate - dermal (%):
- 2.05
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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