Registration Dossier
Registration Dossier
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EC number: 259-583-7 | CAS number: 55302-96-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The respiration inhibition with activated sludge was tested according to OECD guideline n°209 and GLP. The micro-organisms results from activated sludge of the municipal treatment plant of 31137 Hildesheim, Germany. The test was carried out under static conditions with the test item concentrations 10 -32 -100 -320 -1000 mg/L. The respiration rates of the control, reference and test item replicates were measured after a contact time of three hours, and the inhibitory effects of the test and reference items were determined in comparison to the control respiration rates. All the validity criteria of the guideline OECD 209 were fulfilled. The mean inhibition of respiration for the test item replicates ranged from 2% to 56%. The NOEC of the test item was 10 mg/L, the EC10 was 22.2 mg/L (95% CI: 18.0-26.8 mg/L), the EC20 was 51.1 mg/L (95% CI: 42.6-61.9 mg/L) and the EC50 was 603 mg/L (95% CI: 489 -800 mg/L).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 603 mg/L
- EC10 or NOEC for microorganisms:
- 22.2 mg/L
Additional information
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