Propanamide, N-[4-(2,4-dihydroxyphenyl)-2-thiazolyl]-2-methyl-

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 Mar - 24 Apr 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2014

Report date:

2014

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

GLP compliance:

yes (incl. QA statement)

Remarks:

Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Mainz, Germany

Type of method:

capillary method

Test material

Test material information

Constituent 1

Reference substance name:

N-[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]-2-methylpropanamide

EC Number:

807-621-3

Cas Number:

1428450-95-6

Molecular formula:

C13H14N2O3S

IUPAC Name:

N-[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]-2-methylpropanamide

Test material form:

solid: particulate/powder

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

>= 243.3 - <= 246.1 °C

Atm. press.:

ca. 1 013 hPa

Decomposition:

yes

Decomp. temp.:

ca. 190 °C

Sublimation:

no

Remarks on result:

other: estimated accuracy of MP: ±0.5 °C

Any other information on results incl. tables

Melting point/range	Begin	End
First Determination	243.5 °C (516.7 K)	246.3 °C (519.5 K)
Second Determination	243.0 °C (516.2 K)	245.8 °C (519.0 K)

Slightly colour change to pink was observed at approx.190 °C. The test item melted to a red - brown liquid.

After cooling down, the test item did not change back into the original state, but remained red – brown.

In the study 13111801G904 “Determination of the melting point of N-[4-(2,4-dihydroxyphenyl)thiazol-2-yl]isobutyramide according to OECD 102 resp. EU A.1” the test item melted at 243.3 to 246.1 °C (516.5 to 519.3 K) under decomposition. Decomposition was indicated by a colour change of the test item to pink at approx. 190 °C. After cooling down the test item was red brown, which is a clear sign of decomposition as well.

The means between both determinations give the following values for the melting range:

Melting range: 243.3 °C – 246.1 °C (516.5 to 519.3 K).

Standard deviation: 0.4 °C (begin); 0.4 °C (end)

Estimated accuracy: ± 0.5 °C

Validity of the Determination of the Melting Point

All validity criteria were met, as can be taken from the following table.

Parameter	Criterion	Found	Assessment
Difference between duplicate determinations	≤ 0.5 K	0.5 K	valid
Difference between begin and end of melting process	≤ 0.5 K	2.8 K	melting range is stated

test conducted under atmospheric pressure condition, decomposition/sublimation, as well as decomposition /sublimation temperature is not specified

Applicant's summary and conclusion

Conclusions:

NDHPTMPA has a melting point of 243 - 246°C

Executive summary:

NDHPTMPA has a melting point of 243 - 246°C