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EC number: 203-661-5 | CAS number: 109-28-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Read-across with Amides, C8-C22, N-[3-(dimethylamino)propyl]:
Daphnia magna were exposed in a static test to a concentration range of 0.016 to 1 mg/L of the test item. The calculated EC50 after 24 hours and 48 hours were 0.58 (95% CI: 0.38 -1.1) mg/L and 0.28 (95% CL: not determined) mg/L respectively.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.28 mg/L
Additional information
A toxicity study on aquatic invertebrates
with N-[3-(Dimethylamino)propyl]oleamide is not available. Consequently,
read-across was applied using a characteristically similar compound: Amides,
C8-C22, N-[3-(dimethylamino)propyl].
The acute toxicity of the test item to Daphnia magna was assessed
according to the method C2 of the European Directive 92/69/CEE and the
guideline 202 (part I) of the OECD. Daphnia were exposed to a range of
concentrations of the test item dissolved in dilution water. The toxic
effects measured was the inhibition of mobility after exposure periods
of 24 hours and 48 hours. Daphnia were exposed in a static test to
0.016, 0.031, 0.063, 0.125, 0.25, 0.5 and 1 mg test item /L. For each
exposure concentration, the percentage of immobilisation after 24 hours
and 48 hours was recorded. For each exposure concentration, the
percentage of immobilisation after 24 hours and 48 hours was recorded.
As no analytical method was available, effective concentrations have
been calculated using the initial nominal concentrations of the test
substance. The calculated EC50 after 24 hours and 48 hours were 0.58
(95% CL: 0.38 -1.1) mg/L and 0.28 (95% CL: not determined) mg/L,
respectively. The appearance of the test solutions was visually checked
at the beginning and at the end of the test. Solutions were found to be
clear over the period of the test. No precipitation was observed at the
end of the test.
The study was performed in compliance with its quality criteria:
immobilisation in the control did not exceed 10% at the end of the test;
test Daphnia in the control were not trapped at the surface of the
water; concentration of dissolved oxygen in the test vessels remained
above 2 mg/L at the end of the test end pH did not vary by more than 1
unit. It was not possible to check item concentration as values were
lower than the quantification limit of the method used.
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