Registration Dossier
Registration Dossier
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EC number: 203-401-0 | CAS number: 106-47-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- other: lit.search data
- Rationale for reliability incl. deficiencies:
- other: Data from handbook of collection of data.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 988
- Bibliographic source:
- Wagenheim, J. and Bolcfoldi, G; Mouse Lymphoma L5178Y Thymidine Kinase Locus Assay of 50 Compounds; Mutagenesis 3(3):193-205, 1988
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 987
- Bibliographic source:
- Rashid, K A, Arjmand, M, Sandermann, H and Mumma, RO; Mutagenicity of Chloroaniline/Lignin Metabolites in the Salmonella/Microsome Assay; J. Environ. Sci. Health, Part B B22(6): 721-729, 1987
- Reference Type:
- publication
- Title:
- No information
- Author:
- Miyata R et al
- Year:
- 1 981
- Bibliographic source:
- Miyata R et al; Eisei Shikensho Hokoku 99: 60-5 (1981)
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 985
- Bibliographic source:
- Pai, V, Bloomfield, SF and Gorrod, JW; Mutagenicity of N-Hydroxylamines and N-Hydroxycarbamates Towards Strain of Escherichia Coli and Salmonella Thyphimurium; Mutat. Res. 151(2): 201-207, 1985
Materials and methods
- Principles of method if other than guideline:
- No guideline known, only database endpoints.
- GLP compliance:
- not specified
- Type of assay:
- bacterial gene mutation assay
Test material
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- mouse lymphoma L5178Y cells
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- + TA 92 and TA 94
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- E. coli WP2 uvr A
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- without
Results and discussion
Test resultsopen allclose all
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: other: no data
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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