Registration Dossier
Registration Dossier
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EC number: 203-401-0 | CAS number: 106-47-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- other: lit.search data
- Rationale for reliability incl. deficiencies:
- other: Data from handbook of collection of data.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Year:
- 2 003
- Bibliographic source:
- International Programme on Chemical Safety's Concise International Chemical Assessment Documents. Number 48: 4-Chloroaniline (2003). Available from, as of February 22, 2005: http://www.inchem.org/pages/cicads.html
Materials and methods
- Principles of method if other than guideline:
- No guideline known, only database endpoints.
- GLP compliance:
- not specified
- Type of study:
- other: 1/ Guinea pig maximization test 2/ single injection adjuvant test 3/ modified Draize test
Test material
- Reference substance name:
- 4-chloroaniline
- EC Number:
- 203-401-0
- EC Name:
- 4-chloroaniline
- Cas Number:
- 106-47-8
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 4-chloroaniline
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: ethanol
- Concentration / amount:
- intradermal induction with 0.3% PCA, topical induction with 10.0% PCA, and challenge with 2.5%),
Challengeopen allclose all
- Route:
- intradermal
- Vehicle:
- other: ethanol
- Concentration / amount:
- intradermal induction with 0.3% PCA, topical induction with 10.0% PCA, and challenge with 2.5%),
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- concentrations 2.5, 5.0, and 10.0%
- Positive control substance(s):
- not specified
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
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