Registration Dossier
Registration Dossier
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EC number: 201-194-1 | CAS number: 79-30-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Isobutyryl chloride was tested in the Ames reverse mutation assay (GLP compliant study according to OECD guideline 471 and 472) using S. typhimurium strains TA98, TA100, TA1535 and TA1537 and E. coli strain WP2 at 20 to 5000 µg/plate in a standard plate test and 0.8 to 500 µg/plate in a preincubation test, both with and without metabolic activation (BASF AG, 1998). In both tests, the test substance did not lead to an increase in the number of revertant colonies either with or without metabolic activation. A bacteriotoxic effect was observed at doses ≥ 1000 µg/plate in the standard plate test or ≥ 100 µg/plate in the preincubation assay. No precipitation of the test substance was observed.
Short description of key information:
Isobutyryl chloride did not cause gene mutations in an Ames test.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the results of the Ames test, isobutyryl chloride does not need to be classified according to Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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