Registration Dossier
Registration Dossier
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EC number: 201-194-1 | CAS number: 79-30-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound: No data available.
Hydrolysis product: The inhibition of the degradation acitivity of activated sludge is not anticipated when introduced in appropriate low concentrations.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 190 mg/L
Additional information
Parent compound isobutyryl chloride:
No data are available for the test substance isobutyryl chloride (CAS 79 -30 -1). The substance rapidly decomposes in water and form HCL (7647 -01 -0) and isobutyric acid (CAS 79 -31 -2). Therefore, the short-term toxicity to microorganisms is assessed on the basis of data on isobutyric acid.
In a valid 40 hour growth inhibition study, test cultures of the cilliate Tetrahymena pyriformis were exposed to isobutyric acid at five graduate concentrations under static conditions (individual concentrations not reported). The assay was performed in three independent replicate runs on the basis of a preceding range finding test. The IC50 value based on growth inhibition was determined to be 190 mg/L [IC50 (cell density) = 2.15 mg/L] (Schultz, 2011).
In addition, the toxicity of isobutyric acid was tested to the test organism Pseudomonas putida according to German Industrial Standard Guideline DIN 38412 part 8. The 17 -h EC10 and EC50 were determined to be 39 mg/L and 57 mg/L [(nominal, not neutralized) BASF, 1989].
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