Registration Dossier
Registration Dossier
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EC number: 242-670-9 | CAS number: 18917-91-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidance Document No. 28
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Aluminium trilactate
- EC Number:
- 242-670-9
- EC Name:
- Aluminium trilactate
- Cas Number:
- 18917-91-4
- Molecular formula:
- C9H15AlO9
- IUPAC Name:
- Aluminium trilactate
- Details on test material:
- - Name of test material (as cited in study report): Aluminium Lactate
- Analytical purity: Aluminium 2.1 g/100g
- Lot/batch No.: 2426/10
Constituent 1
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: The solution is prepared in tap water by the producer. The test substance was used as given by the producer; no additional test-substance preparation was carried out.
- Duration of exposure:
- 8 h (Times of sampling of receptor fluid: 0; 1; 2; 4; 6; 8; 10 and 24 hours after application)
- Doses:
- nominal dose: 210.74 µg/cm²
Results and discussion
- Absorption in different matrices:
- 0.06% of Aluminium Lactate (expressed as aluminium) was absorbed through human skin over a treatment period of 8 hours under the test conditions used.
Any other information on results incl. tables
Although the mean total recoveries are below the quality criteria put forward in the test guidelines, the study is assessed to be valid in general. The main contents of Aluminium Lactate (measured as aluminium contents) were detected in the washing solution after eight hours (85.69%). Allmost no test substance was found in receptor fluid and receptor chamber washing fluid. In conclusion, 0.06% of Aluminium Lactate (expressed as aluminium) was absorbed through human skin over a treatment period of 8 hours under the test conditions used.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
