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EC number: 701-241-0
CAS number: -
The acute toxicity of Reaction products of C3 alcohols and C3 alkenes
obtained as by-products from the manufacture of propan-2-ol by hydration
of propylene was investigated in an acute inhalation toxicity study and
an acute dermal toxicity study. No deaths occurred in a group of six
rats exposed to a mean achieved atmosphere concentration of 25.4 mg/L
for four hours. It was therefore considered that the acute inhalation
median lethal concentration (4 hr LC50) of Reaction Products of C3
alcohols and C3 alkenes obtained as by-products from the manufacture of
propan-2-ol by hydration of propylene, in the HsdHanTM : WIST strain
rat, was greater than 25.4 mg/L. The acute dermal median lethal dose
(LD50) of the test material in the Wistar strain rat was found to be
greater than 2000 mg/kg bodyweight. Altogether the acute toxicity data
show that Reaction Products of C3 alcohols and C3 alkenes obtained as
by-products from the manufacture of propan-2-ol by hydration of
propylene is of low acute toxicity and does not require classification
for this endpoint
Acute Toxicity: The substance does not meet the criteria for
classification and labelling for this endpoint, as set out in Regulation
(EC) NO. 1272/2008. Specific target organ, Neurotoxicity: According to
CLP classification criteria, the substance does meet the criteria for
classification and labelling for this endpoint (STOT single exposure
category 3, H336 - May cause drowsiness or dizziness), as set out in
Regulation (EC) No. 1272/2008.
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