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EC number: 701-241-0
CAS number: -
The acute toxicity of Reaction products of C3 alcohols and C3 alkenes
obtained as by-products from the manufacture of propan-2-ol by hydration
of propylene was investigated in an acute inhalation toxicity study and
an acute dermal toxicity study. No deaths occurred in a group of six
rats exposed to a mean achieved atmosphere concentration of 25.4 mg/L
for four hours. It was therefore considered that the acute inhalation
median lethal concentration (4 hr LC50) of Reaction Products of C3
alcohols and C3 alkenes obtained as by-products from the manufacture of
propan-2-ol by hydration of propylene, in the HsdHanTM : WIST strain
rat, was greater than 25.4 mg/L. The acute dermal median lethal dose
(LD50) of the test material in the Wistar strain rat was found to be
greater than 2000 mg/kg bodyweight. Altogether the acute toxicity data
show that Reaction Products of C3 alcohols and C3 alkenes obtained as
by-products from the manufacture of propan-2-ol by hydration of
propylene is of low acute toxicity and does not require classification
for this endpoint
Acute Toxicity: The substance does not meet the criteria for
classification and labelling for this endpoint, as set out in Regulation
(EC) NO. 1272/2008. Specific target organ, Neurotoxicity: According to
CLP classification criteria, the substance does meet the criteria for
classification and labelling for this endpoint (STOT single exposure
category 3, H336 - May cause drowsiness or dizziness), as set out in
Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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