Reaction mass of 2-methylpentane and Hexanol, branched and linear and diisopropyl ether

Endpoint summary

Key value for chemical safety assessment

Acute toxicity: via inhalation route

Endpoint conclusion

Dose descriptor:

LC50

Value:

25 400 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

LD50

Value:

2 000 mg/kg bw

Additional information

The acute toxicity of Reaction products of C3 alcohols and C3 alkenes obtained as by-products from the manufacture of propan-2-ol by hydration of propylene was investigated in an acute inhalation toxicity study and an acute dermal toxicity study. No deaths occurred in a group of six rats exposed to a mean achieved atmosphere concentration of 25.4 mg/L for four hours. It was therefore considered that the acute inhalation median lethal concentration (4 hr LC50) of Reaction Products of C3 alcohols and C3 alkenes obtained as by-products from the manufacture of propan-2-ol by hydration of propylene, in the HsdHanTM : WIST strain rat, was greater than 25.4 mg/L. The acute dermal median lethal dose (LD50) of the test material in the Wistar strain rat was found to be greater than 2000 mg/kg bodyweight. Altogether the acute toxicity data show that Reaction Products of C3 alcohols and C3 alkenes obtained as by-products from the manufacture of propan-2-ol by hydration of propylene is of low acute toxicity and does not require classification for this endpoint

Justification for classification or non-classification

Acute Toxicity: The substance does not meet the criteria for classification and labelling for this endpoint, as set out in Regulation (EC) NO. 1272/2008. Specific target organ, Neurotoxicity: According to CLP classification criteria, the substance does meet the criteria for classification and labelling for this endpoint (STOT single exposure category 3, H336 - May cause drowsiness or dizziness), as set out in Regulation (EC) No. 1272/2008.