Registration Dossier
Registration Dossier
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EC number: 603-562-0 | CAS number: 13223-43-3
Endpoint summary
Administrative data
Description of key information
Skin:
A primary skin irritation test was conducted with rabbits to determine the potential for ADTP to produce irritation after a single topical application. Under the conditions of this study, the test substance did not cause skin irritation.
Eye:
A primary eye irritation test was conducted with rabbits to determine the potential for ADTP to produce irritation from a single instillation via the ocular route. Under the conditions of this study, the test substance caused iritis and conjunctival irritation which cleared by 48 hours.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin:
The key study for skin irritation was conducted in accordance with U.S. EPA Health Effects Test Guidelines, OPPTS 870.2500 (1998). The study was conducted in line with GLP. A reliability rating of 1 according to the criteria of Klimisch, 1997.
Eye:
The key study for eye irritation was conducted in accordance with U.S. EPA Health Effects Test Guidelines, OPPTS 870.2400 (1998). The study was conducted in line with GLP. A reliability rating of 1 according to the criteria of Klimisch, 1997.
Justification for classification or non-classification
Skin:
The results do not meet the the criteria set out in Directive 67/548/EEC (DSD) or Regulation (EC) 1272/2008 (CLP) therefore classification for skin irritation is not required.
Eye:
The results do not meet the the criteria set out in Directive 67/548/EEC (DSD) or Regulation (EC) 1272/2008 (CLP) therefore classification for eye irritation is not required.
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