Registration Dossier
Registration Dossier
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EC number: 203-756-1 | CAS number: 110-31-6
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Amides, C16 and C18-C20 (even numbered, unsaturated), N,N’-ethylenebis does not exhibit bioaccumulation potential.
Key value for chemical safety assessment
Additional information
There is no data available on the biodegradation potential of Amides, C16 and C18-C20 (even numbered, unsaturated), N,N’-ethylenebis. In order to fulfil the standard information requirements set out in Annex IX, 9.3.2, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from a structurally related substance is conducted.
A detailed justification for the grouping of chemicals and read-across is provided in the technical dossier (see IUCLID Sections 5 and 13).
The bioaccumulation potential of Amides, C16 and C18-C20 (even numbered, unsaturated), N,N’-ethylenebis was assessed in a read across approach using the structurally related substance Amides, C16-C18 (even), N,N'-ethylenebis. The potential for bioconcentration of Amides, C16-C18 (even), N,N'-ethylenebis in a freshwater fish, Cyprinus carpio, was investigated in one study from the Japanese Ministry of International Trade and Industry (MITI, 1988). The study was conducted according to OECD Guideline 305. The fishes were exposed to two concentrations of the test substance (0.830 mg/L and 0.083 mg/L) for a period of 6 weeks, under flow-through water conditions. At the end of the test, estimated BCFs were <0.7 and <6.2 at the 0.830 and 0.083 mg/L concentrations, respectively. Therefore, the test substance did not exhibit potential for bioconcentration in fish species. Additional information about this endpoint could be gathered through BCF calculation using BCFBAF (v3.00), a subroutine of the EPI Suite™ computer program (Cuesta, 2013). The estimated BCF value for the main compounds ranged from 0.893 to 0.907 L/kg, and thus it supports the experimental result.
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