Registration Dossier
Registration Dossier
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EC number: 203-242-7 | CAS number: 104-83-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Noakes and Sanderson, Brit. J. industr. Med. 26, 1969, 59
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- α,4-dichlorotoluene
- EC Number:
- 203-242-7
- EC Name:
- α,4-dichlorotoluene
- Cas Number:
- 104-83-6
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 1-chloro-4-(chloromethyl)benzene
- Details on test material:
- p-Chlorobenzyl chloride, solid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Average weight at study initiation: female: 167 g, male: 173 g
- Housing: Makrolon cages typ III
- Diet: "Altromin R 1324"
- Water: tap water (ad libitum)
ENVIRONMENTAL CONDITIONS
- Temperature: 22 +/- 1.5 °C
- Humidity: 60 +/- 5 %
- Photoperiod: 12 h dark, 12 h light
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- Amount applied: in polyethylene glycol, once administered
- Doses:
- 1000, 1100, 1200, 1400, 1500, 1600 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 287 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- Necropsy of dead and of surviving animals showed no signs of pathological changes.
Applicant's summary and conclusion
- Executive summary:
In this acute dermal toxicity study Wistar rats were dermally exposed to p-chlorobenzyl chloride in polyethylen glycol at doses of 1000 mg/kg bw (5/sex), 1100 mg/kg bw (5/sex), 1200 mg/kg bw (5/sex), 1400 mg/kg bw (5/sex), 1500 mg/kg bw (5/sex) and 1600 mg/kg bw (5/sex).
Animals then were observed for 14 days.
Necropsy of dead and of surviving animals showed no signs of pathological changes.
The LD 50 value was established to be 1287 mg/kg bw for both sexes.
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