Registration Dossier
Registration Dossier
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EC number: 203-242-7 | CAS number: 104-83-6
Endocrine disrupter mammalian screening – in vivo (level 3)
Administrative data
- Endpoint:
- endocrine disrupter mammalian screening – in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Endocrine mediated effects of two benzene related compounds, 1-chloro-4-(chloromethyl)benzene and 1,3-diethyl benzene , based on subacute oral toxicity studies using rats
- Author:
- K. Yamasaki, S. Ishii, T. Kinuno, Y. Minobe
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 407
- GLP compliance:
- not specified
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- 0, 10, 50, 250 mg/kg/day
- Duration of treatment / exposure:
- 28 d
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (nominal)
- Dose / conc.:
- 10 mg/kg bw/day (nominal)
- Dose / conc.:
- 50 mg/kg bw/day (nominal)
- Dose / conc.:
- 250 mg/kg bw/day (nominal)
Results and discussion
- Endocrine disrupting potential:
- negative
Applicant's summary and conclusion
- Conclusions:
- Rats were fed with up to 250 mg/kg bw/day for at least 28 days. No endocrine effects were observed.
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