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Toxicological information

Endocrine disrupter mammalian screening – in vivo (level 3)

Administrative data

Endpoint:
endocrine disrupter mammalian screening – in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Endocrine mediated effects of two benzene related compounds, 1-chloro-4-(chloromethyl)benzene and 1,3-diethyl benzene , based on subacute oral toxicity studies using rats
Author:
K. Yamasaki, S. Ishii, T. Kinuno, Y. Minobe
Year:
2012
Bibliographic source:
Food and Chemical Toxicology

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD 407
GLP compliance:
not specified

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Details on oral exposure:
0, 10, 50, 250 mg/kg/day
Duration of treatment / exposure:
28 d
Doses / concentrationsopen allclose all
Dose / conc.:
0 mg/kg bw/day (nominal)
Dose / conc.:
10 mg/kg bw/day (nominal)
Dose / conc.:
50 mg/kg bw/day (nominal)
Dose / conc.:
250 mg/kg bw/day (nominal)

Results and discussion

Endocrine disrupting potential:
negative

Applicant's summary and conclusion

Conclusions:
Rats were fed with up to 250 mg/kg bw/day for at least 28 days. No endocrine effects were observed.