Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-974-7 | CAS number: 7783-00-8
Ecotoxicological information
Long-term toxicity to fish
Currently viewing:
Administrative data
- Endpoint:
- fish, juvenile growth test
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well performed study. Effect concentrations based on measured selenium concentrations.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of sodium selenite to rainbow trout fry
- Author:
- Hunn JB, Hamilton SJ, Buckler DR
- Year:
- 1 987
- Bibliographic source:
- Water Research 21, 233-238
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Salmo gairdneri (rainbow trout) fry were exposed to waterborne selenium as sodium selenite for a period of 90 days under flow-through conditions using a proportional diluter. Five concentrations and a control were tested. Test concentrations were analytically verified.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium selenite
- EC Number:
- 233-267-9
- EC Name:
- Sodium selenite
- Cas Number:
- 10102-18-8
- Molecular formula:
- H2O3Se.2Na
- IUPAC Name:
- disodium selenite
- Details on test material:
- - Name: sodium selenite
- Analytical purity: 98%
- Source: Sigma Chemical Company
- No further information stated
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples were taken from all treatments, frequency not stated.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- see test conditions
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: rainbow trout
- Source: no data
- Length at study initiation: 21.7 mm
- Weight at study initiation: 75 mg
- Fish were fed a commercial diet supplemented with live nauplii of brine shrimp (ad libitum) for the first 30 days of the study.
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 90 d
Test conditions
- Hardness:
- 272 mg CaCO3/L
- Test temperature:
- 12 +/- 1 °C
- pH:
- 7.4
- Dissolved oxygen:
- 237 mg CaCO3/L
- Nominal and measured concentrations:
- Measured concentrations: control, 7.8, 12.4, 21.0, 47.2 and 99.5 ug/L
- Details on test conditions:
- TEST SYSTEM
- Type of flow-through: proportional diluter
- No. of organisms per vessel: 20 fry
- No. of vessels per concentration (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: well water
- Dilution water parameters: Well water was characterized by pH 7.4, alkalinity 237 mg/L as CaCO3 , hardness 272 mg/L as CaCO3 and selenium < 0.4 ug/L.
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality, length and body weight
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 90 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 21 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- element
- Remarks:
- Se
- Basis for effect:
- mortality
- Duration:
- 90 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 47.2 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se
- Basis for effect:
- mortality
- Duration:
- 90 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 47.2 µg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- element
- Remarks:
- Se
- Basis for effect:
- length
- Remarks:
- and body weight
- Duration:
- 90 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 99.5 µg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se
- Basis for effect:
- length
- Remarks:
- and body weight
- Reported statistics and error estimates:
- Split plot in time analysis of variance + Least Significant Difference test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Reliable (Klimisch 2) study in which Salmo gairdneri (rainbow trout) fry were exposed to selenium as sodium selenite for a period of 90 days under flow-through conditions using a proportional diluter. Five concentrations and a control were tested. Test concentrations were analytically verified. The most sensitive endpoint investigated was mortality with a 90-day NOEC and LOEC of 21 and 47.2 µg Se/L, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
