Registration Dossier
Registration Dossier
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EC number: 241-644-4 | CAS number: 17671-26-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Basic data given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- analytical purity/composition of test substance not specified, limited documentation, no necropsy
- Principles of method if other than guideline:
- The acute oral toxicity was tested in rats upon oral administration of doses at 1000 and 5000 mg/kg bw.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Octyl octanoate
- EC Number:
- 218-980-5
- EC Name:
- Octyl octanoate
- Cas Number:
- 2306-88-9
- Molecular formula:
- C16H32O2
- IUPAC Name:
- octyl octanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 180 g (mean body weight)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other:
- Doses:
- 1000 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior application and 48 h, 1 week, 2 weeks after application
- Necropsy of survivors performed: no
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during the observation period.
- Clinical signs:
- other: No overt signs of toxicity were observed up to the end of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
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