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EC number: 241-644-4 | CAS number: 17671-26-0
Endpoint summary
Administrative data
Description of key information
Additional information
There are no data available for the aquatic toxicity of lauryl nonanoate (CAS 17671-26-0). Therefore, the aquatic hazard of the target substance was assessed by a read-across approach to structurally and chemically related substances in order to fulfill the standard information requirements laid down in Annex XI, 1.5, of the REACH Regulation (EC) No 1907/2006.
According to Article 13 (1) of this regulation, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for aquatic toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across). In regard to the general rules for grouping of substances and the read-across approach, the regulation specifies (Annex XI, Item 1.5) that substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity.
The target substance lauryl nonanoate (CAS 17671-26-0) consists of an unbranched fatty acid with a chain length of nine carbon atoms and an unbranched fatty alcohol (C12). The source substance tetradecanoic acid, tetradecyl ester (CAS 3234-85-3) consists of a fatty acid and fatty alcohol with a chain length of 14 carbon atoms each. The source substance fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) is characterized by fatty acid chain lengths ranging from C8 to 10 and alcohol components with chain lengths ranging from C12 to 18. The source substance octyl octanoate (CAS 2306-88-9) is an ester of a saturated C8 fatty acid and a C8 alcohol.
Based on the high degree of similarity between the structural and physico-chemical properties, the selected source substances are considered suitable representatives for the assessment of the aquatic toxicity of the target substance and it is assumed that the target substance will exhibit a similar ecotoxicological profile as the source substances. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).
For the assessment of the aquatic toxicity of the target substance lauryl nonanoate (CAS 17671-26-0), GLP guideline studies are available for all three trophic levels (fish, aquatic invertebrates and algae) by means of the read-across approach. The compiled data for acute toxicity (fish, aquatic invertebrates and algae) and chronic toxicity (aquatic invertebrates and algae) neither indicate any short-term nor any long-term toxicity towards aquatic freshwater organisms up to the limit of the water solubility of the source substances. Furthermore, no toxicity towards aquatic microorganisms of activated sludge was recorded.
Due to the low water solubility, long-term testing on aquatic invertebrates was necessary to fully assess the potential aquatic toxicity. The available read-across study was performed with the source substance fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) and resulted in a NOELR (21 d) ≥ 10.0 mg/L (nominal, OECD 211), indicating no effects on reproduction up to the limit of water solubility after 21 d exposure. The test item concentration in the test solution was not analytically verified due to technical limitations related to the low water solubility of the test substance (< 0.05 mg/L) for which no reliable analytical method could be developed. Consequently, the occurrence of bioavailable concentrations of the target substance in the water phase at sufficiently high concentrations for acute or chronic effects to occur in aquatic organisms is judged to be highly unlikely.
Therefore, it can be concluded that lauryl nonanoate (CAS 17671-26-0) does not cause short-term or long-term toxicity in aquatic organisms up to the limit of water solubility (2.43 µg/L) and does not affect the degradation process in commercial sewage treatment plants.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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