Registration Dossier
Registration Dossier
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EC number: 223-026-6 | CAS number: 3697-42-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
A mutagenicity study (reverse mutation assay) in Salmonella typhimurium according to OECD guideline 471 with plate incorporation test and preincubation test each with and without metabolic activation by S9 mix from Arochlor 1254-induced rat liver is reported. The concentration of the test substance was based on the observations of a preliminary test with strain TA 100 in which pronounced to complete cytotoxicity was observed at >= 1 μg/plate. Under the conditions of the assay where positive controls exerted the expected mutagenic effects, chlorhexidine dihydrocloride caused no mutagenic effect in the Salmonella typhimurium strains TA 98, TA 100, TA 102, TA 1535 and TA 1537 neither in the plate incorporation nor in the preincubation test each carried out with and without metabolic activation.
Additional information
Justification for classification or non-classification
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