Registration Dossier
Registration Dossier
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EC number: 223-026-6 | CAS number: 3697-42-5
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Principles of method if other than guideline:
- Method: other (measurement): 2001/59/EC C.19 (2001)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
- Radiolabelling:
- no
- Test temperature:
- ambient (24°C-24.5°C)
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC Pump SP8810, Spectra-Physics Inc.; Differential Refractometer, Knauer Inc.
MOBILE PHASES
Mobile Phase A
- Type: methanol / water (purified) 55/45 (v/v)
- pH: put to pH3 with H3PO4 (85%)
Mobile Phase B
- Type: methanol / buffer solution 55/45 (v/v)
- pH: pH7.5
REFERENCE SUBSTANCES
- Identity: Urea, Acetanilide, Monuron, Triapethenol, Linuron, Fenthion, Trifluralin - Type:
- log Koc
- Value:
- > 3.9 dimensionless
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient on soil (log Koc) of Chlorhexidine dihydrochloride was estimated to be log Koc >3.9.
Reference
log Koc > 3.9
The test substance did not elute from the chromatographic column. So the log Koc of Chlorhexidine dihydrochloride is higher than the highest Koc-value of the calibration substances which was Trifluralin with a log Koc of 3.9.
Description of key information
A GLP adsorption/desorption study according to the EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
was performed. As a result the test substance did not elute from the chromatographic column. So the log Koc of Chlorhexidine dihydrochloride is higher than the highest Koc-value of the calibration substances which was Trifluralin with a log Koc of 3.9 => log Koc > 3.9
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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