Registration Dossier
Registration Dossier
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EC number: 215-114-8 | CAS number: 1303-00-0
Endpoint summary
Administrative data
Description of key information
Only field-based bioaccumulation factors based on total As concentrations in organisms and their environment were selected for the assessment of the bioaccumulation of As in aquatic or soil organisms. This ensures that biota As burdens are in equilibrium with As concentrations in their environment and are exposed via all relevant uptake routes.
A total of 206 reliable field-based BAF values were identified for As accumulation in freshwater fish, while 55 BAF values were identified for marine fish. Species mean BAF (sBAF) values for fish range from 0.4 to 1093 L/kg wet weight for 64 freshwater species and between17.5 to 1511 L/kg wet weight for 27 marine species. BAF values significantly decrease with increasing arsenic water concentrations and differ between the freshwater and marine environment. The median of freshwater and saltwater fish species-mean BAF values is 14 L/kg wet weight and 619 L/kg wet weight, respectively. These values are selected for the chemical safety assessment.
Seventy-four field-based biota to soil accumulation factors (BSAF) for As in earthworms were identified, ranging from 0.01 to 1.75, with a median of 0.22 (dry weight based), indicating that earthworms generally accumulated arsenic to levels much lower than those measured in the associated soils. The median BSAF soil-earthworm value of 0.22 (dimensionless, dry weight based) was selected for the chemical safety assessment.
Additional information
Only few water accommodated fraction (WAF) based acute aquatic ecotoxicity data are available for the poorly soluble substance gallium arsenide (GaAs). For metals and poorly soluble metal compounds, WAF testing should not be used and ecotoxicity information should be derived with tests on a soluble metal salt and differences in solubility addressed by results from transformation/dissolution tests on the poorly soluble compound. Upon dissolution, GaAs yields both soluble gallium and arsenic ions. Because the available toxicity data show that As ions are more toxic in the environment compared to Ga ions, the ecotoxicity of GaAs is predicted based on read across from GaAs to soluble inorganic As compounds. In order to still account for the potential contribution of Ga ions to toxicity of GaAs in the environment, the toxicity results for As ions are not corrected for their abundance in GaAs, which means that the toxicity of Ga is considered similar as As. This is a worst-case scenario based on the available toxicity data for soluble Ga and As compounds.
For further justification of the read-across approach between GaAs and arsenic, see also the justification document attached in IUCLID section 13).
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