Registration Dossier
Registration Dossier
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EC number: 219-006-1 | CAS number: 2312-35-8
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7th November 1988 to 16th November 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Guideline 63-10
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- no
- pKa:
- > 12
- Remarks on result:
- other: estimated value
- Conclusions:
- Under the conditions of the test, it was determined that the test material does not exhibit a dissociation constant in the range of pKa 2 to 12. It was estimated that the test material has a pKa > 12.
- Executive summary:
In a GLP compliant dissociation constant study conducted in accordance with guideline 63-10, the dissociation constant of the test material was determined. Under the conditions of the test, the substance does not exhibit a dissociation constant in the range of pKa 2 to 12 and is estimated to have a pKa > 12.
Reference
Quantitation
Spectrophotometric method
No meaningful difference in spectral absorbance occurs at usable wavelengths. Results below 220 nm for the basic sample solutions (i.e. pH 11.8 and 12.7) should be ignored. Hydroxide ion is a strong absorber below 220 nm - the UV/Vis spectrophotometer cannot correct for the resulting high blank thus leading to anomalous results below 220 nm. No loss of concentration due to physisorption of the test substance on the glassware or degradation of the substance due to hydrolysis was observed.
Potentiometric method
No inflection attributable to the presence of the test material can be seen.
Description of key information
Dissociation constant estimated pKa > 12; study conducted in accordance with Guideline 63-10; Tang and Rose (1988)
Key value for chemical safety assessment
Additional information
In a GLP compliant dissociation constant study conducted in accordance with a standard guideline, the dissociation constant of the test material was determined. Under the conditions of the test, the substance does not exhibit a dissociation constant in the range of pKa 2 to 12 and is estimated to have a pKa > 12.
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