Registration Dossier
Registration Dossier
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EC number: 456-830-2 | CAS number: 745070-61-5
Endpoint summary
Administrative data
Description of key information
No adverse effects were evident after 28- and 90 days of daily dosing up to the highest dose of approximately 1000 mg/kg bw/day.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
In conclusion, the oral administration of Propanamide, N,N',N''-1,3,5-benzenetriyltris[2,2- dimethyl- (9CI)] for 28 consecutive days as well as via the diet over a period of 3 months revealed no signs of toxicity in male and female Wistar rats up to the highest dose tested. In the feeding study the rats received a maximum concentration of 15000 ppm. Therefore, the no observed adverse effect level (NOAEL) was 15000 ppm for male (961 mg/kg bw/d) and female Wistar rats (1104 mg/kg bw/d).
Justification for classification or non-classification
There are conclusive data that classification of the test item with regard to repeated dose toxicity is not necessary.
The test item is not classified for this endpoint in accordance with Directive 67/548/EEC or with the CLP Regulation (EC) No 1272/2008 reflecting GHS regulations.
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