Registration Dossier
Registration Dossier
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EC number: 216-223-3 | CAS number: 1530-32-1
Endpoint summary
Administrative data
Description of key information
Hydrolysis
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C or 1.4 yrs and 51 days at pH 7 and 8 with a second order hydrolysis rate constant of 0.16 L/mol-sec, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
Additional information
Hydrolysis
Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. The average percentage recovery of the test chemical after 5 days was determined to be 96.5, 97.5 and 98.6% at pH 4, 7 and 9, respectively. As no hydrolysis of test chemical was observed for a period of 5 days, the half-lives was determined to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
For the test chemical, the hydrolysis half-life was determined. Although half-life value of test chemical was not known, but it was noted that chemical is not susceptible to hydrolysis and thus it was reported to be hydrolytically stable. On the basis of this, test chemical isconsidered to be not hydrolysable.
In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C or 1.4 yrs and 51 days at pH 7 and 8 with a second order hydrolysis rate constant of 0.16 L/mol-sec, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable.
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