Registration Dossier
Registration Dossier
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EC number: 282-208-3 | CAS number: 84144-87-6 Flue dust and ash containing vanadium resulting from the combustion of vanadium-bearing fuel oil.
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a dermal sensitization studywith Vanadium Concentratein AOO (acetone:olive oil 4:1), 20 eight to nine weeks old female CBA/CaOlaHsd micewere tested in an local lymph node assay (LLNA). Based on the results of the preliminary test the test item was assessed for sensitising properties at concentrations of 6.25 %, 12.5 % and 25 % (w/v). 20 animals were separated in four test groups, three treatment groups and the fourth group served as control animals which received the vehicle only. Clinical observations and weight changes were recorded daily. Positive control was P-Phenylenediamine 1 %, administered daily to the animals.
None of the three tested concentrations of the test item reached the stimulation index of 3, therefore the EC3 value (derived by linear interpolation) could not be calculated. The results of radioactivity determination were supported by the means of the ear thickness per group, which showed no significant difference compared to the negative control.
Migrated from Short description of key information:
The sensitizing potential of Vanadium concentrate was assessed in a local lymph node assay (LLNA) according to OECD 429 (BSL 2010c).
Justification for classification or non-classification
According to OECD 429 and the criteria given in Annex I of Regulation (EC) 1272/2008, the test item Vanadium Concentrate did no show sensitising potential in an LLNA and therefore should not be regarded as dermal sensitiser.
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