Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Toxicokinetic Assessment of Lithium Nickel Potassium Oxide (KDLNO) Using Physico-Chemical Properties and Toxicological Study Data
- Remarks:
- See attached justification document with "Toxicokinetic Assessment of Lithium Nickel Potassium Oxide (KDLNO) Using Physico-Chemical Properties and Toxicological Study Data"
- Justification for type of information:
- See attached justification document with "Toxicokinetic Assessment of Lithium Nickel Potassium Oxide (KDLNO) Using Physico-Chemical Properties and Toxicological Study Data".
- Conclusions:
- Based upon the available data, the systemic absorption of the substance KDLNO is expected to
be negligible regardless of the route of exposure. Inhalation exposure is not expected under
normal use conditions based upon the particle size as manufactured and processed and life-cycle
information for the substance. The absence of systemic effects in the acute and repeated-dose
toxicity studies in rats indicate that absorption of the substance was very limited; effects were
limited to the tissues in direct contact with the test substance. Effects related to dissolved nickel
were not observed, even at the highest dose tested. In the unlikely event that the substance is
absorbed, KDLNO is expected to dissolve to the separate metal ions (nickel, potassium, and
lithium). The amounts of potassium and lithium in the substance are very low, so even if
absorbed, they cannot contribute more than a negligible quantity to the blood or other tissues.
All three ions should be excreted rapidly in urine.
Reference
Description of key information
Based upon the available data, the systemic absorption of the substance KDLNO is expected to
be negligible regardless of the route of exposure. Inhalation exposure is not expected under
normal use conditions based upon the particle size as manufactured and processed and life-cycle
information for the substance. The absence of systemic effects in the acute and repeated-dose
toxicity studies in rats indicate that absorption of the substance was very limited; effects were
limited to the tissues in direct contact with the test substance. Effects related to dissolved nickel
were not observed, even at the highest dose tested. In the unlikely event that the substance is
absorbed, KDLNO is expected to dissolve to the separate metal ions (nickel, potassium, and
lithium). The amounts of potassium and lithium in the substance are very low, so even if
absorbed, they cannot contribute more than a negligible quantity to the blood or other tissues.
All three ions should be excreted rapidly in urine.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
