Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- The shake-flask and HPLC methods to determine the partition coefficient of the substance in accordance with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Methods 107 and 117 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 and 13 April 2004, respectively, were considered to be inappropriate for this test item.
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Remarks on result:
- not determinable
- Executive summary:
The shake-flask and HPLC methods to determine the partition coefficient of the substance in accordance with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Methods 107 and 117 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 and 13 April 2004, respectively, were considered to be inappropriate for this test item.
Therefore, it was considered that the partition coefficient would be estimated via calculation of the ratio of the n-octanol solubility over the water solubility.
However, as both the n-octanol solubility results and the water solubility results indicated “less than” values, it was not feasible to determine a partition coefficient for the test item.
Reference
Description of key information
The shake-flask and HPLC methods to determine the partition coefficient of the substance in accordance with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Methods 107 and 117 of the OECD Guidelines for Testing of Chemicals, 27 July 1995 and 13 April 2004, respectively, were considered to be inappropriate for this test item.
Therefore, it was considered that the partition coefficient would be estimated via calculation of the ratio of the n-octanol solubility over the water solubility.
However, as both the n-octanol solubility results and the water solubility results indicated “less than” values, it was not feasible to determine a partition coefficient for the test item.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
