Registration Dossier
Registration Dossier
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EC number: 246-836-1 | CAS number: 25321-14-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to national standard methods with acceptable restrictions, isomers not specified and purity not given
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Occupational photosensitivity to dinitrotoluene.
- Author:
- Emtestam L and Forsbeck M
- Year:
- 1 985
- Bibliographic source:
- Photodermatology 2, 120-121.
- Reference Type:
- secondary source
- Title:
- Dinitrotoluene (isomers mixture), CAS No.: 25321-14-6
- Author:
- OECD SIDS
- Year:
- 2 004
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: patient study
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Standard photo-patch test procedure of the Scandinavian Photodermatitis Research Group (Contact Dermatitis, 155-158, 1982)
- Principles of method if other than guideline:
- One patient was patch test using Finn chambers technique with three ICDRC standard subctances. Subsequently photopatch testing was done by irradiating with UVA.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dinitrotoluene
- EC Number:
- 246-836-1
- EC Name:
- Dinitrotoluene
- Cas Number:
- 25321-14-6
- Molecular formula:
- C7H6N2O4
- IUPAC Name:
- 1-methyl-2,4-dinitrobenzene; 2-methyl-1,3-dinitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): Ditrotoluene (in peanut oil)
- Analytical purity: no data
- Isomers composition: no data
Constituent 1
Method
- Type of population:
- occupational
- Controls:
- 10 control persons for patch test and 5 control persons for phtopatch test
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test and photopatch test
ADMINISTRATION
- Vehicle / solvent: peanut oil
- Concentrations: 0.5% and 1%, respectively
- Volume applied: no data
- Removal of test substance: after 24 hours
Results and discussion
- Results of examinations:
- Patch-test:
10 control persons: all tests with DNT gave negative results
the patient: negative reaction to DNT
Photopatch-test:
5 control persons: all tests with DNT gave negative results
the patient: DNT 0.5 % (+++) and 1.0 % (+++)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
