Reaction mass of 3-(octanoyloxy)propyl decanoate and propane-1,3-diyl didecanoate and propane-1,3-diyl dioctanoate

Endpoint summary

Description of key information

No data on the test item is available. With the read-across substances the following results were obtained:

Fish:

CAS 68583-51-7: EC50 > 39 mg/L, NOEC = 39 mg/L

CAS 853947-59-8: EC50 > 14 mg/L, NOEC = 14 mg/L

Daphnia:

CAS 68583-51-7: EC50 >2.7 mg/L, NOEC = 2.7 mg/L

CAS 853947-59-8: EC50 >2.0 mg/L, NOEC = 2.0 mg/L

Algae:

CAS 68583-51-7: EC50 >5.3 mg/L, EC10 >5.3 mg/L, NOEC ≥ 5.3 mg/L

CAS 853947-59-8: EC50 >3.0 mg/L, EC10 >3.0 mg/L, NOEC ≥ 3.0 mg/L

Microorganisms:

CAS 68583-51-7: EC10 > 0.9 g/L, NOEC = 0.9 g/L

CAS 853947-59-8: EC10 > 1.1 g/L, NOEC = 1.1 g/L

Additional information

No data on the test item is available. With the read-across substances the following results were obtained:

Fish:

The toxicity of the read-across substance CAS 68583-51-7 to fish (Danio rerio) was determined according to the principles of OECD 203. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of lethality over a period of 96 hours. The study was conducted under semi-static conditions with renewal of the test solution after 24 h. A stock solution of 1 g/L was prepared with deionised water. The concentration was calculated from the new solutions to be 39 mg/L. Two replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. No lethality was observed. The following results were determined: EC50 >39 mg/L, NOEC = 39 mg/L, LOEC > 39 mg/L.

The toxicity of the read-across substance CAS 853947-59-8 to fish (Cyprinus carpio) was determined according to the principles of OECD 203. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of lethality over a period of 96 hours. The study was conducted under semi-static conditions with renewal of the test solution after 24 h. A stock solution of 1 g/L was prepared with deionised water. The concentration was calculated from the new solutions to be 14 mg/L. Two replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. No lethality was observed. The following results were determined: EC50 >14 mg/L, NOEC = 14 mg/L, LOEC > 14 mg/L.

Daphnia:

The toxicity of the read-across substance CAS 68583-51-7 to Daphnia magna was determined according to the principles of OECD 202. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of immobilsation over a period of 48 hours. The study was conducted under static conditions. A stock solution of 1 g/L was prepared with deionised water. One concentration was tested: 2.7 mg/L. Five replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. The concentrations of the test item in the test concentration and the control were analytically verified by TOC Infrared analyser at the start and the end of exposure. The measured concentrations were in the range of 20 % of the nominal value. Therefore, all effect values given are based on the nominal test item concentrations. No immobilistion was observed. The following results were determined: EC50 >2.7 mg/L, NOEC = 2.7 mg/L, LOEC > 2.7 mg/L.

The toxicity of the read-across substance 853947-59-8 to Daphnia magna was determined according to the principles of OECD 202. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of immobilsation over a period of 48 hours. The study was conducted under static conditions. A stock solution of 1 g/L was prepared with deionised water. One concentration was tested: 2.0 mg/L. Five replicates were tested for the test item concentration and for the control. The environmental conditions were within the acceptable limits. The analytical determination of the stability of the test item was tested separately. Concentrations of 0.5, 1.2 and 2.4 mg/L were analyzed after 24, 48 and 72 h. The recovery rate was >80%, therefor nominal values were used for the test. During the test no concentrations were measured. No immobilistion was observed. The following results were determined: EC50 >2.0 mg/L, NOEC = 2.0 mg/L, LOEC > 2.0 mg/L.

Algae:

The toxicity of the read across substance CAS 68583-51-7 to the unicellular freshwater green alga Desmodesmus subspicatus was determined according to the principles of OECD 201. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of growth rate and yield over a period of 72 hours. The study was conducted under static conditions with an initial cell density of 20.000 cells/mL. A stock solution of 1 g/L was prepared with deionised water. Five concentrations were tested in a geometrical series (nominal): 0.59 - 0.99 - 1.8 - 2.9 - 5.3 mg/L. Five replicates were tested for each test item concentration and eight replicates for the control. The environmental conditions were within the acceptable limits. The concentrations of the test item in all test concentrations and the control were analytically verified by TOC Infrared analyser at the start and the end of exposure. The measured concentrations were in the range of 20 % of the nominal values of all concentrations. Therefore, all effect values given are based on the geometric mean measured test item concentrations. The following geometric mean measured results were determined: EC50 >5.3 mg/L, EC10 >5.3 mg/L, NOEC ≥ 5.3 mg/L.

The toxicity of the read-across substance CAS 853947-59-8 to the unicellular freshwater green alga Desmodesmus subspicatus was determined according to the principles of OECD 201. The aim of the study was the determination of NOEC, LOEC, EC10- , EC20- and EC50-values of growth rate and yield over a period of 72 hours. The study was conducted under static conditions with an initial cell density of 20.000 cells/mL. A stock solution of 1 g/L was prepared with deionised water. One concentration was tested: 3.0 mg/L. Five replicates were tested for the test item concentration and eight replicates for the control. The environmental conditions were within the acceptable limits. The analytical determination of the stability of the test item was tested separately. Concentrations of 0.5, 1.2 and 2.4 mg/L were analyzed after 24, 48 and 72 h. The recovery rate was >80%, therefor nominal values were used for the test. During the test no concentrations were measured. Therefore, all effect values given are based on the geometric mean measured test item concentrations. The following geometric mean measured results were determined: EC50 >3.0 mg/L, EC10 >3.0 mg/L, NOEC ≥ 3.0 mg/L.

Microorganisms:

In the oxygen-consumption test according to Hüls AG (Dr. Schöberl) the respiration inhibition of the read across substance CAS 68583-51-7 was determined. Four concentrations of 0.99, 9.9, 99 and 990 mg/L were used. After incubation of 4.75 h with Pseudomonas putida Migula the respiration of the organisms was stimulated and not inhibited. Therefor the EC10 and EC50 > 0.99 g/L.

In the oxygen-consumption test according to OECD 209 the respiration inhibition of the read across substance CAS 853947-59-8 was determined. The concentrations of 45.8, 91.6, 183.2, 366.4 and 1099 mg/L were used. After incubation of 3 h with activated sludge the respiration of the organisms was stimulated and not inhibited. Therefor the EC10 and EC50 > 1.1 g/L.