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EC number: 258-380-0 | CAS number: 53126-67-3
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-12-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- An excess amount of test item is added into fixed amounts of 1-octanol, then shaken until saturation. Afterwards the mass concentrations of the test in saturated solutions are determined by a HPLC-ELSD-method with external calibration.
- GLP compliance:
- no
- Key result
- Medium:
- n-octanol
- Solubility:
- 2.017 g/L
- Temp.:
- 20 °C
- Test substance stable:
- not determined
- Details on results:
- The individual results differ by 5.6 % for 1-octanol solubility and thus were regarded as valid.
- Conclusions:
- The solubility in 1- octanol of the test item was determined to be 2.017 ± 0.1162 g/L at 20 °C
- Executive summary:
A study was conducted to determine the solubility of the test item in 1-octanol. Therefore 9 flasks were prepared containing 50 mg of the test item and 20 mL of 1-octanol and were shaken for 24, 48 and 72 h respectively. After 24 h the test item concentration in 3 flasks were determine using a HPLC-ELSD method. The solubility in 1- octanol of the test item was determined to be 2.017 ± 0.1162 g/L at 20 °C
Reference
Individual results
Flask |
Shaking Duration (h) |
Weighted sample in mg/20 ml |
Sum of peak areas of the signals |
1-Octanol solubility of Afilan SPC pa mg/l |
Average /day |
Average mg/l |
Standard deviation mg/l |
OCT-1 |
24 |
52.6 |
5176384 |
2126.1 |
1967.2 |
2017 |
116.2 |
OCT-2 |
24 |
55.5 |
4706068 |
1810.3 |
|||
OCT 3 |
24 |
53.5 |
5165807 |
1965.1 |
|||
OCT-4 |
48 |
51.7 |
5302757 |
2010.7 |
1978.1 |
||
OCT-5 |
48 |
51.2 |
4980619 |
1903.1 |
|||
OCT-6 |
48 |
53.4 |
5332210 |
2020.4 |
|||
0CT-7 |
72 |
54.2 |
5336161 |
2021.7 |
2105.7 |
||
0CT-8 |
72 |
55.3 |
5847010 |
2189.2 |
|||
0CT-9 |
72 |
56.4 |
5592872 |
2106.3 |
Description of key information
The solubility in 1- octanol of the test item was determined to be 2.017 ± 0.1162 g/L at 20 °C
Key value for chemical safety assessment
- At the temperature of:
- 20 °C
- Solubility in organic solvents at 20°C:
- 2.017 g/L
Additional information
A study was conducted to determine the solubility of the test item in 1-octanol. Therefore 9 flasks were prepared containing 50 mg of the test item and 20 mL of 1-octanol and were shaken for 24, 48 and 72 h respectively. After 24 h the test item concentration in 3 flasks were determined using a HPLC-ELSD method. The solubility in 1- octanol of the test item was determined to be 2.017 ± 0.1162 g/L at 20 °C
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