Registration Dossier
Registration Dossier
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EC number: 273-727-6 | CAS number: 69012-27-7 By-product of chromium refining containing oxides of aluminum, magnesium and silicon.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Evaluation of an authoritative institution
Data source
Reference
- Reference Type:
- other: evaluation
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Evaluation of available data by authorative institution
- GLP compliance:
- no
Test material
- Reference substance name:
- Perlite
- EC Number:
- 603-442-8
- IUPAC Name:
- Perlite
- Reference substance name:
- 93763-70-3
- EC Number:
- 618-970-4
- Cas Number:
- 93763-70-3
- IUPAC Name:
- 93763-70-3
- Details on test material:
- Commercial perlite is a naturally occurring glass of volcanic origin, which, when heated, expands to form a product of low density, high surface area, and low thermal conductivity. The ore is essentially an amorphous, hydrated glassy volcanic rock consisting of fused sodium potassium aluminium silicate of variable composition. The chemical composition depends on the particular ore body in which it is found. The colour of crude perlite ranges from transparent light grey to glossy black. Perlite exists as crude and as expanded material.
Perlite ores and expanded perlite are about 75% non-crystalline silicate. Both may contain small amounts (<1% to 5.8%) of quartz.
Constituent 1
Constituent 2
Test animals
- Species:
- other: review of rat and mouse data
Administration / exposure
- Route of administration:
- oral: unspecified
- Details on oral exposure:
- Review of available data
- Doses:
- Review of available data
- No. of animals per sex per dose:
- Review of available data
- Details on study design:
- Review of available data
- Statistics:
- Review of available data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- > 10 000 mg/kg bw
Any other information on results incl. tables
The committee did not find data on the acute respiratory or dermal toxicity of perlite. The acute oral LD50 in mice was >12,960 mg/kg bw. No signs of toxicity were reported. In 2 other unpublished studies, the oral LD50 in rats was stated to be greater than 10,000 mg/kg bw, the highest dose tested.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The acute oral LD50 of perlite in rat and mouse is over 10000 mg/kg bw.
- Executive summary:
The committee did not find data on the acute respiratory or dermal toxicity of perlite. The acute oral LD50 in mice was >12,960 mg/kg bw. No signs of toxicity were reported. In 2 other unpublished studies, the oral LD50 in rats was stated to be greater than 10,000 mg/kg bw, the highest dose tested.
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