Registration Dossier
Registration Dossier
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EC number: 928-812-9 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Not irritating to the skin.
Not irritating to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
No data are available on skin and eye irritation for hydrocarbons, C13-C20, n-alkanes, isoalkanes, cyclics, aromatics (40-60%). However, there are reliable data available for the analogue substance hydrocarbons, C11 -C20, n-alkanes, isoalkanes, cyclics, aromatics (2-30%). Thus, read-across was conducted.
Skin irritation
10 rats were exposed to 2 mL hydrocarbons, C11-C20, n-alkanes, isoalkanes, cyclics, aromatics (2-30%) via occlusive patch for 24 hours under GLP (DHC Colvent Chemie GmbH, 1985). Well-defined erythema was noted upon removal of the test patches in all animals exposed to the test substance, generally persisting for a further 24 hours. After 72 hours, all animals were free of dermal irritation except one female rabbit displayed an erythema score of 2.0 at the 72 hour observation. The average erythema score (24, 48, and 72 hours) was 1.35. Post mortem examination of all animals killed at termination revealed an area of diffuse subcutaneous haemorrhage beneath the dorsal patch site in one male. However, no other findings considered to be related to treatment were observed.
Eye irritation
The eyes of three female rabbits were instilled with 0.1 mL of hydrocarbons, C11-C20, n-alkanes, isoalkanes, cyclics, aromatics (2-30%) (DHC Colvent Chemie GmbH, 1975). All animals exhibited a conjunctival redness score of 1 at the 1 hour time point. All irritation scores were zero at the 24 and 48 hour observation time points. This study was conducted under GLP, but there was no observation at 72 hours. Because of the mean (24-48 hour) score of 0.0 the test substance is considered to be not an eye irritant in rabbits.
Respiratory irritation
There are no data available.
The following information is taken into account for any hazard / risk assessment:
Not irritating to the skin.
Not irritating to the eyes.
Justification for classification or non-classification
The available data on skin and eye irritation are conclusive but not sufficient for classification.
There are no studies that warrant classification as a respiratory irritant.
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