Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-090-8 | CAS number: 555-31-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- aluminium(3+) ion tris(propan-2-olate)
- Cas Number:
- 555-31-7
- Molecular formula:
- C₉H₂₁AlO₃
- IUPAC Name:
- aluminium(3+) ion tris(propan-2-olate)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- ANIMAUX D'ESSAI
- Source: Rouché SA, Couhé, France
- Poids à l'initiation de l'étude: 2,5 kg
- Logement: pas de données
- Diète / eau: pas de données
CONDITIONS ENVIRONNEMENTALES: pas de données
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100 mg
- Observation period (in vivo):
- 1, 24, 48, 72, 96 h et 7 jours après installation
- Number of animals or in vitro replicates:
- 6 males
- Details on study design:
- ENLÈVEMENT DE SUBSTANCE D'ESSAI
- Lavage (si terminé): test supplémentaire avec lavage après 4 et 30 secondes
SYSTÈME DE NOTATION: indice d'irritation oculaire (Kay & Calandra)
OUTIL UTILISÉ POUR ÉVALUER LE SCORE: pas de données
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- >= 58.7 - <= 60.5
- Remarks on result:
- positive indication of irritation
- Remarks:
- irritant extreme
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 16.8
- Remarks on result:
- positive indication of irritation
- Remarks:
- irritant sévère
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 1.8
- Remarks on result:
- positive indication of irritation
- Remarks:
- irritant
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable because of methodological limitations
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable because of methodological limitations
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable because of methodological limitations
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable because of methodological limitations
- Irritant / corrosive response data:
- non spécifié
- Other effects:
- non spécifié
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- La substance est un irritant oculaire sévère
- Executive summary:
L'irritation oculaire de 56 produits chimiques a été testée dans l'œil du lapin.avec et sans rinçage,
en utilisant une procédure conforme aux principales exigences de trois protocoles.à savoir ceux proposés
par l'Association Française de Normalisation (AFNOR) en 1982 et par. l'Organisation pour la
Coopération et développement en 1979 pour l'expérimentation des che-
Autorités françaises (Journal Oficiel, 21 avril 1971, page 3862, ibid., 5 juin 1973, page 3953) pour l'expérimentation
cosmétiques et articles de toilette.Les résultats obtenus ont été utilisés pour déterminer dans quelle mesure l'évaluation
Le potentiel d'irritation d'un produit chimique a été affecté par les différences entre les trois protocoles
des temps d'observation prescrits, l'inclusion et le moment du rinçage, le nombre d'animaux utilisés et
la procédure d'interprétation.Des conclusions ont également été tirées sur l'influence de l'état physique
pH d'un matériau sur son potentiel irritant et sur le niveau d'irritation qui nécessite l'utilisation de
protection.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
