Registration Dossier
Registration Dossier
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EC number: 239-387-8 | CAS number: 15356-60-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only a very short abstract available
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- A dermal LD50 study was conducted on a group of 10 rabbits, and a single application of 5 g/kg was administered. The animals were observed for mortality and/or clinical signs for 14 day.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no further details given
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- no further details given
- Duration of exposure:
- no further details given
- Doses:
- a single application of 5 g/kg
- No. of animals per sex per dose:
- 10 rabbits were exposed
- Control animals:
- not specified
- Details on study design:
- A dermal LD50 study was conducted on a group of 10 rabbits, and a single application of 5 g/kg was administered. The animals were observed for mortality and/or clinical signs for 14 day.
- Statistics:
- no further details given
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- no mortality observed
- Clinical signs:
- other: no adverse clinical cisgns reported
- Gross pathology:
- no further details given
- Other findings:
- no further details given
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- LD50 > 5000 mg/kg
l-menthol appears to be non toxic in tested conditions.
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