Registration Dossier
Registration Dossier
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EC number: 239-387-8 | CAS number: 15356-60-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The study is not GLP compliant, no guidelines were strictely followed and only short documentation is available (publication).
Data source
Reference
- Reference Type:
- publication
- Title:
- The antiseptic value and toxicity of menthol isomers
- Author:
- Franck Wokes
- Year:
- 1 932
- Bibliographic source:
- Journal of Pharmacy and Pharmacology 5 (1932), pp. 233–244
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- L-menthol
- EC Number:
- 218-690-9
- EC Name:
- L-menthol
- Cas Number:
- 2216-51-5
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
- Details on test material:
- none provided
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Doses:
- Concentration of testing material in vehicle was between 10% and 20%.
2 to 4 mg/g bw of the solution was orally given to the mice. - No. of animals per sex per dose:
- 10 mice per dose
sex was not specified - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: several days
The mice were deprived of food several hours before gavage to ensure optimal absorption of l-menthol.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3.4 other: g/kg bw
- Based on:
- dissolved
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The LD50 for L-menthol was found to be 3 g/kg bw in the study conditions.
L-menthol is then considered non toxic.
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