Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-153-9 | CAS number: 10045-95-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity in vitro:
Bacterial reverse mutation assay:
Thompson (2013) performed an Ames (preliminary toxicity test, plate incorporation assay and preincubation method) test with S typhimurium strains TA1535, TA1537, TA98 and TA100 and Escherichia coli strain WP2uvrA in the presence and absence of metabolic activation (10% S9).
Following test concentrations were applied in triplicate:
Preliminary toxicity test: 0, 0.15, 0.5, 1.5, 5, 15, 50, 150, 500, 1500 and 5000 µg/plate (neodymium trinitrate as active ingredient) Mutation test - experiment 1:
0, 5, 15, 50, 150, 500, 1500 and 5000 µg/plate (neodymium trinitrate as active ingredient)
0, 6, 18, 60, 181, 604, 1811 and 6035 µg/plate (based on the test item (including a water content of 20.7%))
Mutation test - experiment 2:
0, 5, 15, 50, 150, 500, 1500 and 5000 µg/plate (neodymium trinitrate as active ingredient)
0, 6, 18, 60, 181, 604, 1811 and 6035 µg/plate (based on the test item (including a water content of 20.7%))
The test item caused a visible reduction in the growth of the bacterial background lawn and/or substantial reductions in revertant colony frequency for all of the tester strains in the presence and absence of S9-mix at 5000 µg/plate in each experiment. Negative and positive controls responded adequately. No significant increases in the frequency of revertant colonies were recorded for any of the strains of bacteria, at any dose level either with or without metabolic activation or exposure method.
Justification for selection of genetic toxicity endpoint
There is only one study available for this endpoint.
Short description of key information:
Genetic toxicity in vitro:
In an Ames test according to OECD Guideline 471, EU Method B.13/14 and EPA OPPTS 870.5100 (Thompson, 2013), neodymium trinitrate proved to be negative for mutagenicity with and without metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available information, the substance does not need to be classified for genotoxicity under CLP or DSD.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
