Registration Dossier
Registration Dossier
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EC number: 610-992-2 | CAS number: 53378-52-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 18, 2011 - July 7, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Principles of method if other than guideline:
- In the applied HPLC method an external calibration was used. The pH of the aqueous solution was not determined, however the pKa of the test substance was determined to be 5.75±0.02 at 20 °C.
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Sodium O,O-diisobutyl phosphorothioate
- EC Number:
- 610-992-2
- Cas Number:
- 53378-52-2
- Molecular formula:
- C8 H18 O3 P S . Na
- IUPAC Name:
- Sodium O,O-diisobutyl phosphorothioate
- Test material form:
- other: grease-like solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): S10821; AERO® 6697 Promoter distilled
- Name: Sodium diisobutyl monothiophoshate
- CAS: 53378-52-2
- Molecular formula: C8H18O3PS.Na
- Molecular weight: 248.26
- Storage condition of test material: not indicated in the study report
- Batch no.: 20154-189-B
- Purity: 87.3%
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -2
- Temp.:
- 23 °C
- Remarks on result:
- other: The pH of the investigated solutions has not been determined.
- Details on results:
- The log Pow of the test substance was determined to be -2.00 ± 0.02, at 23 °C.
Applicant's summary and conclusion
- Conclusions:
- The log Pow of the test substance was determined to be -2.00 ± 0.02, at 23 °C, in accordance to OECD 107 guideline and EU method A.8.
- Executive summary:
Using the HPLC method according to OECD TG 107, the log Pow of the substance at ca. 23°C has been determined to be -2.
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