Registration Dossier
Registration Dossier
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EC number: 212-146-4 | CAS number: 765-43-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Principles of method if other than guideline:
- Type: Ames Test with/without microsomal enzyme fraction (S9 of rat liver on house prepared). Method: OECD 471, method B14 92/69/EEC
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Cyclopropyl methyl ketone
- EC Number:
- 212-146-4
- EC Name:
- Cyclopropyl methyl ketone
- Cas Number:
- 765-43-5
- Molecular formula:
- C5H8O
- IUPAC Name:
- 1-cyclopropylethan-1-one
- Details on test material:
- Cyclopropyl methyl ketone >99%/ colourless liquid.
Constituent 1
Method
- Test concentrations with justification for top dose:
- For preliminary toxicity study was 0, 50, 150, 500, 1500 and 5000 μg/plate and used in the strain of Salmonella typhimurium TA100. For the main toxicity study was used the same dosage of the preliminary toxicity study.
Results and discussion
- Additional information on results:
- No significant increase in the frequency of revertant colonies was recorded for any of the bacterial strains with any dose of the test material, either with or without metabolic activation. The test material was found to be non-mutagenic under the conditions of this test.
Any other information on results incl. tables
| Species | Other Species | Strain | Other Strain | Metabolic Activation | Genotoxic Effect | Conclusion |
| Bacteria | - | TA100 | - | with/without | Negative | Negative |
| Bacteria | - | TA1535 | - | with/without | Negative | Negative |
| Bacteria | - | TA98 | - | with/without | Negative | Negative |
| Bacteria | - | TA1537 | - | with/without | Negative | Negative |
Applicant's summary and conclusion
- Conclusions:
- non-mutagenic
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