Registration Dossier
Registration Dossier
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EC number: 225-059-1 | CAS number: 4635-59-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, essential details given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard. 50 µl of the test substance were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. The report describes findings after 1 and 24 hours and at the end of the observation period. For final evaluation, the findings after 48 and 72 hours from the raw data were taken into account.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorobutyryl chloride
- EC Number:
- 225-059-1
- EC Name:
- 4-chlorobutyryl chloride
- Cas Number:
- 4635-59-0
- Molecular formula:
- C4H6Cl2O
- IUPAC Name:
- 4-chlorobutanoyl chloride
- Details on test material:
- Name of the test substance used in the study report: gamma-Chlorbuttersäurechlorid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- ca. 0.05 ml
- Duration of treatment / exposure:
- 1, 24 h
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h - 24 h - 8d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corneal opacity
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information
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