Registration Dossier
Registration Dossier
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EC number: 202-681-1 | CAS number: 98-56-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Remarks:
- Literature data
Data source
Reference
- Reference Type:
- publication
- Title:
- Application of molecular encapsulation for toxicology studies: toxicokinetics of p-chloro-alfa, alfa, alfa-trifluorotoluene in alfa-cyclodextrin or corn oil vehicles in male F334 rats.
- Author:
- Yuan, J., Jameson, C.W., Goehl, T.J., Collins, B,J., Purdie, W., Judd, L.
- Year:
- 1 991
- Bibliographic source:
- Toxicol. Appl. Pharmacol., 11, 107-115
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chloro-α,α,α-trifluorotoluene
- EC Number:
- 202-681-1
- EC Name:
- 4-chloro-α,α,α-trifluorotoluene
- Cas Number:
- 98-56-6
- Molecular formula:
- C7H4ClF3
- IUPAC Name:
- 1-chloro-4-(trifluoromethyl)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: Tween 80 aquaous solution
- Duration and frequency of treatment / exposure:
- single injection in the tail vein
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4.7 mg/kg bw
- No. of animals per sex per dose / concentration:
- 2
Results and discussion
Main ADME resultsopen allclose all
- Type:
- distribution
- Results:
- very rapid
- Type:
- excretion
- Results:
- half-life = 20 hours
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Toxicokinetic parameters:
- half-life 1st: 20 h
Applicant's summary and conclusion
- Conclusions:
- The elimination of the test item from the blood after intravenous injection followed a triexponential equation with very rapid distribution in the tissues and a biological elimination half-life of about 20 hours.
- Executive summary:
The toxicokinetics of p-chlorobenzotrifluride were studied in 2 male F344 rats following single intravenous administration of a tween 80 aqueous solution. The elimination of the test item from the blood after intravenous injection followed a triexponential equation with very rapid distribution in the tissues and a biological elimination half-life of about 20 hours.
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