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EC number: 947-528-6
CAS number: -
One Guideline Study for the Endpoint "Gene Mutation in Bacteria"
At this tonnage band, no further studies are neede.
Two valid experiments were performed.
The study procedures described in this report were based on the most
recent OECD and
The test item Bis(neodecanoyloxy)dioctylstannane was tested in the
reverse mutation assay with five strains of Salmonella typhimurium
TA100, TA102 and TA1535).
The test was performed in two experiments in the presence and absence of
activation, with +S9 standing for presence of metabolic activation, and
–S9 standing for
absence of metabolic activation.
In the first experiment, the test item (dissolved in ethanol) was tested
up to concentrations
of 5 μL/plate in the absence and presence of S9-mix in the strains
TA97a, TA98, TA100,
TA102 and TA1535 using the plate incorporation method.
The test item showed no precipitates on the plates at any of the
The bacterial background lawn was not reduced at any of the
concentrations and no relevant
decrease in the number of revertants was observed in all bacteria
strains. The test item
showed no signs of toxicity towards the bacteria strains in both the
absence and presence
of metabolic activation.
The results of this experiment showed that none of the tested
concentrations showed a
significant increase in the number of revertants in all tested strains,
in the presence and the
Based on the first experiment, the test item was tested up to
concentrations of 5 μL/plate in
the absence and presence of S9-mix in all bacteria strains using the
(= second experiment).
No bacterial background lawn and no bacteria growth could be observed at
the highest concentration
(5 μL/plate) in two bacteria strains (TA97a and TA102). The lower
were not affected.
The results of this experiments showed that the test item caused no
increase in the number
of revertants in all bacteria strains compared to the solvent control,
in both the absence and
presence of metabolic activation. The test item did not induce a
dose-related increase in the
number of revertants colonies in all strains, in the presence and
absence of metabolic activation.
The available information is conclusive but not sufficient for
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